Prozone Phenomenon in Haemagglutination Reactions

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Rh ANTIBODIES AND THE PROZONE PHENOMENON BY

In 1942 Taylor, Race, Prior, and Ikin reported an anti-Rh serum which failed to agglutinate Rhpositive cells in saline suspension except when diluted. They thought that this prozone was due to antigen and antibody not being present in optimal proportions, and that the mechanism was similar to that of the zones that occur in precipitation reactions. Wiener (1944) described incomplete Rh antibodi...

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Rh antibodies and the prozone phenomenon.

In 1942 Taylor, Race, Prior, and Ikin reported an anti-Rh serum which failed to agglutinate Rhpositive cells in saline suspension except when diluted. They thought that this prozone was due to antigen and antibody not being present in optimal proportions, and that the mechanism was similar to that of the zones that occur in precipitation reactions. Wiener (1944) described incomplete Rh antibodi...

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Case Report Prozone-like phenomenon in travellers with fatal malaria: report of two cases

Malaria diagnosis remains a concern in non-endemic countries, with rapid diagnosis being crucial to improve patients’ outcome. Rapid diagnostic tests have high sensitivity but they also have flaws and false-negative results that might jeopardize malaria diagnosis. Some falsenegative results might relate to a prozone-like effect. The authors describe two patients with false-negative rapid diagno...

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Incidence and risk factors for the prozone phenomenon in serologic testing for syphilis in a large cohort.

BACKGROUND The prozone phenomenon is known to be associated with high antibody titers; other associations, such as host factors, have not been elucidated. METHODS A retrospective analysis was conducted to evaluate the incidence of the prozone phenomenon of the syphilis rapid plasma reagin (RPR) test among 46 856 clinical samples, between June 2010 and June 2013. Logistic regression was used t...

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Haemagglutination of bluetongue virus (BTV) was demonstrated for the first time by making use of a purified preparation of the virus. The reaction was found to be independent of variations in the pH, temperature, buffer system and origin of the erythrocytes used in the test. A haemagglutination inhibition test, subsequently developed, was demonstrated to be serotype specific. The storage of the...

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ژورنال

عنوان ژورنال: BMJ

سال: 1951

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.2.4733.708